I just ran into a different way of triggering what seems to be a similar issue. Editing a client with DCO enabled, unchecking DCO, then Saving/Applying:
Nov 29 23:36:45 openvpn 10586 event_wait : Interrupted system call (fd=-1,code=4)
Nov 29 23:36:45 openvpn 10586 SIGTERM received, sending exit notification to peer
Nov 29 23:36:45 openvpn 10586 Attempting to send data packet while data channel offload is in use. Dropping packet
Nov 29 23:36:45 openvpn 10586 Failed to poll for packets: Device not configured (errno=6)
Nov 29 23:36:45 openvpn 10586 Failed to poll for packets: Device not configured (errno=6)
Nov 29 23:36:46 openvpn 17080 WARNING: file '/var/etc/openvpn/client3/up' is group or others accessible
Nov 29 23:36:46 openvpn 17080 OpenVPN 2.6_git amd64-portbld-freebsd14.0 [SSL (OpenSSL)] [LZO] [LZ4] [MH/RECVDA] [AEAD] [DCO]
Nov 29 23:36:46 openvpn 17080 library versions: OpenSSL 1.1.1q-freebsd 5 Jul 2022, LZO 2.10
Nov 29 23:36:46 openvpn 17080 MANAGEMENT: unix domain socket listening on /var/etc/openvpn/client3/sock
Nov 29 23:36:46 openvpn 17080 NOTE: the current --script-security setting may allow this configuration to call user-defined scripts
Nov 29 23:36:46 openvpn 17080 Initializing OpenSSL support for engine 'rdrand'
Nov 29 23:36:46 openvpn 17080 WARNING: experimental option --capath /var/etc/openvpn/client3/ca
Nov 29 23:36:46 openvpn 17080 Outgoing Control Channel Authentication: Using 256 bit message hash 'SHA256' for HMAC authentication
Nov 29 23:36:46 openvpn 17080 Incoming Control Channel Authentication: Using 256 bit message hash 'SHA256' for HMAC authentication
Nov 29 23:36:46 openvpn 17080 TCP/UDP: Preserving recently used remote address: [AF_INET]<SERVER_IP>:1194
Nov 29 23:36:46 openvpn 17080 Socket Buffers: R=[42080->42080] S=[57344->57344]
Nov 29 23:36:46 openvpn 17080 UDPv4 link local (bound): [AF_INET]127.0.0.1:0
Nov 29 23:36:46 openvpn 17080 UDPv4 link remote: [AF_INET]<SERVER_IP>:1194
Nov 29 23:36:46 openvpn 17080 TLS: Initial packet from [AF_INET]<SERVER_IP>:1194, sid=ddda52d8 1821a463
Nov 29 23:36:46 openvpn 10586 Failed to delete peer: Invalid argument (errno=22)
Nov 29 23:36:46 openvpn 10586 /sbin/route delete -net 172.17.105.0 172.17.5.1 255.255.255.0
Nov 29 23:36:46 openvpn 10586 ERROR: FreeBSD route delete command failed: external program exited with error status: 1
Nov 29 23:36:46 openvpn 10586 Closing DCO interface
Nov 29 23:36:46 openvpn 10586 /sbin/ifconfig ovpnc3 172.17.5.2 -alias
Nov 29 23:36:46 openvpn 10586 FreeBSD ip addr del failed: external program exited with error status: 1
Nov 29 23:36:46 openvpn 10586 /sbin/ifconfig ovpnc3 destroy
Nov 29 23:36:47 openvpn 10586 /usr/local/sbin/ovpn-linkdown ovpnc3 1500 0 172.17.5.2 255.255.255.0 init
Nov 29 23:36:47 openvpn 21022 Flushing states on OpenVPN interface ovpnc3 (Link Down)
Nov 29 23:36:47 openvpn 17080 VERIFY WARNING: depth=0, unable to get certificate CRL: CN=gw.<SERVER_DOMAIN>
Nov 29 23:36:47 openvpn 17080 VERIFY WARNING: depth=1, unable to get certificate CRL: CN=<SERVER_DOMAIN>-internal
Nov 29 23:36:47 openvpn 17080 VERIFY OK: depth=1, CN=<SERVER_DOMAIN>-internal
Nov 29 23:36:47 openvpn 17080 VERIFY KU OK
Nov 29 23:36:47 openvpn 17080 Validating certificate extended key usage
Nov 29 23:36:47 openvpn 17080 ++ Certificate has EKU (str) TLS Web Server Authentication, expects TLS Web Server Authentication
Nov 29 23:36:47 openvpn 17080 VERIFY EKU OK
Nov 29 23:36:47 openvpn 17080 VERIFY OK: depth=0, CN=gw.<SERVER_DOMAIN>
Nov 29 23:36:47 openvpn 10586 SIGTERM[soft,exit-with-notification] received, process exiting
Nov 29 23:36:48 openvpn 17080 Control Channel: TLSv1.3, cipher TLSv1.3 TLS_AES_256_GCM_SHA384, peer certificate: 2048 bit RSA, signature: RSA-SHA256
Nov 29 23:36:48 openvpn 17080 [gw.<SERVER_DOMAIN>] Peer Connection Initiated with [AF_INET]<SERVER_IP>:1194
Nov 29 23:36:49 openvpn 17080 SENT CONTROL [gw.<SERVER_DOMAIN>]: 'PUSH_REQUEST' (status=1)
Nov 29 23:36:49 openvpn 17080 PUSH: Received control message: 'PUSH_REPLY,route 10.0.5.0 255.255.255.0,dhcp-option DOMAIN <SERVER_DOMAIN>,dhcp-option DNS 172.17.5.1,route 172.17.105.0 255.255.255.0,client-nat dnat 172.17.105.0 255.255.255.0 10.0.5.0,route-gateway 172.17.5.1,topology subnet,ping 10,ping-restart 60,ifconfig 172.17.5.2 255.255.255.0,peer-id 1,cipher AES-256-GCM,key-derivation tls-ekm'
Nov 29 23:36:49 openvpn 17080 Options error: option 'route' cannot be used in this context ([PUSH-OPTIONS])
Nov 29 23:36:49 openvpn 17080 Options error: option 'dhcp-option' cannot be used in this context ([PUSH-OPTIONS])
Nov 29 23:36:49 openvpn 17080 Options error: option 'dhcp-option' cannot be used in this context ([PUSH-OPTIONS])
Nov 29 23:36:49 openvpn 17080 Options error: option 'route' cannot be used in this context ([PUSH-OPTIONS])
Nov 29 23:36:49 openvpn 17080 Options error: option 'client-nat' cannot be used in this context ([PUSH-OPTIONS])
Nov 29 23:36:49 openvpn 17080 OPTIONS IMPORT: timers and/or timeouts modified
Nov 29 23:36:49 openvpn 17080 OPTIONS IMPORT: --ifconfig/up options modified
Nov 29 23:36:49 openvpn 17080 OPTIONS IMPORT: route-related options modified
Nov 29 23:36:49 openvpn 17080 OPTIONS IMPORT: peer-id set
Nov 29 23:36:49 openvpn 17080 OPTIONS IMPORT: data channel crypto options modified
Nov 29 23:36:49 openvpn 17080 ROUTE_GATEWAY 177.231.47.1/255.255.255.0 IFACE=vmx0.99 HWADDR=00:50:56:b2:85:60
Nov 29 23:36:49 openvpn 17080 TUN/TAP device /dev/tun3 opened
Nov 29 23:36:49 openvpn 17080 /sbin/ifconfig ovpnc3 172.17.5.2/24 mtu 1500 up
Nov 29 23:36:49 openvpn 17080 FreeBSD ifconfig failed: external program exited with error status: 1
Nov 29 23:36:49 openvpn 17080 Exiting due to fatal error